Sinestrol in Latin. Veterinary drug "Sinestrol": indications and contraindications, instructions

002087/01

Tradename: Sinestrol

International nonproprietary name:

Hexestrol

Dosage form:

Solution for injection in oil 0.1% and 2%.

Compound:

Sinestrol - 1g or 20g;
olive oil or peach oil - up to 1 liter.

Description: Transparent oily liquid of light yellow or golden yellow color.

Pharmacotherapeutic group:

Estrogen.

ATS code:

Pharmacological properties:

Pharmacodynamics:
Sinestrol is a hormonal drug; its chemical structure differs from steroid estrogen hormones, but its biological and medicinal properties close to them.
The therapeutic effect of sinestrol is identical to the effect of follicular hormone preparations, both in terms of the effect on the uterus and mammary glands, and in terms of the effect on the cardiovascular, nervous system and on general condition female body. Under the influence of sinestrol, the blood supply to the genital organs increases and the processes of endometrial proliferation are activated. Sinestrol can cause engorgement and enlargement of the mammary glands due to the proliferation of glandular tissue.
The drug has the property of eliminating vegetative-vascular disorders that occur in women due to depletion of ovarian function (menopause, condition after castration).
Pharmacokinetics:
Absorption high, has a “first pass” effect through the liver.
Excretion kidneys; depending on the physiological state (individual phases of the menstrual cycle), age and other conditions, the rate of excretion is different. Indications for use:

conditions associated with insufficient ovarian function (primary and secondary amenorrhea, oligomenorrhea, dysmenorrhea);
hypoplasia of the genital organs;
menopausal and post-castration disorders;
infertility; weakness of labor, post-term pregnancy;
prostate cancer, breast cancer;

Contraindications:

Hypersensitivity to the components of the drug.
Pregnancy; liver and kidney diseases; mastopathy, endometriosis, uterine bleeding of unknown etiology, as well as various forms of hyperestrogenism; diseases associated with increased blood clotting ability, malignant and benign neoplasms of the genital and other organs in women (under the age of 60 years).
Inflammatory diseases of the female genital organs (salpingoophoritis, endometritis), hyperfollicular stage of menopause, tendency to uterine bleeding.

Directions for use and dosage:

The drug is administered in the form of oil solutions intramuscularly.

For hypogenitalism, primary amenorrhea and underdevelopment of the uterus, use 1-2 mg intramuscularly daily for 4-6 weeks or more. If there is an effect, then progesterone or pregnin is prescribed for 6-8 days. With secondary amenorrhea, 1-2 mg of Sinestrol is prescribed for 15-20 days, then progesterone or pregnin is prescribed for 6-8 days at the indicated dose;
For oligomenorrhea - 1 mg intramuscularly every day or every other day during the first half of the intermenstrual period;
For infertility due to underdevelopment of the uterus - 1 mg intramuscularly in the first 7-8 days after menstruation;
For menopausal disorders, 0.5-1 mg is prescribed. The duration of treatment is individualized;
For prostate adenoma, 2 ml of a 2% solution of Sinestrol (0.04 g) is administered daily for 30 days. During the year, another 2-3 courses of 20 days are carried out with an interval of 2-3 months.
For prostate cancer, 3-4 ml of a 2% solution of Sinestrol (0.06-0.08 g) is administered intramuscularly daily for 2 months, then 0.5-1 ml of a 2% solution per day intramuscularly. The total dose and duration of treatment depend on changes in the prostate gland, the presence or absence of metastases, general condition and degree of feminization;
For breast cancer in women over 60 years of age, a 2% Sinestrol solution is used. Administer daily, starting with 1 ml per day, then the daily dose is gradually increased to 5 ml. Through careful observation, the optimal dose is determined and administered over a long period of time.

Higher doses of Sinestrol - for adults (intramuscular):

single dose - 0.002 g (2 ml of 0.1% solution)
daily - 0.003 g.

In the treatment of malignant neoplasms:

the highest single dose is 0.06 g (Zml 2% solution);
highest daily dose-0.1g (5ml 2% solution).

Side effect:

Nausea, vomiting, dizziness, rash, eyelid swelling, erythropenia.
With long-term use: in men - feminization (decreased sexual function, swelling and pigmentation of the nipples, reduction in the size of the testicles); in women - sclerosis of the ovaries, impaired sodium metabolism (peripheral edema), metrorrhagia.

special instructions
The drug should be prescribed only by the attending physician, under his supervision, after an accurate diagnosis has been established. Before use, the drug should be heated to 30-40°C. If crystals fall out, heat in a boiling water bath until they are completely dissolved.

Interaction with other drugs:

Antiestrogenic drugs (clomiphene citrate, etc.), used to treat infertility, can block estrogen receptors and weaken the effect of estrogens.
Folic acid and thyroid medications enhance the effect of sinestrol.
The side effects of sinestrol are reduced under the influence of progestins (gestagens), which serves as the basis for the joint prescription of sinestrol with gestagenic drugs (pregnin, progesterone, etc.). Sinestrol enhances the effect of lipid-lowering drugs, diuretics, antiarrhythmics, antihypertensive drugs, and indirect anticoagulants.

Overdose
When taking large doses, toxic liver damage is possible; excessive proliferation of the endometrium and uterine bleeding, peripheral edema, increased blood clotting. Severe feminization in men (decreased sexual function, swelling and pigmentation of the nipples, reduction in the size of the testicles).

Release form
0.1% and 2% solution in oil in ampoules of 1 ml; 10 pieces per pack.

Storage conditions:

List B. In a place protected from light and out of reach of children.

Best before date
5 years. Do not use the drug after the expiration date indicated on the package.

International nonproprietary name
Hexestrol
Latin name
Synoestrolu
Pharmaceutical group
Estrogen agents
Synonyms
Hexestrol, Cycloestrol, Dihydrostil-bestrol, Estren, Estronal, Folliplex, Hexanestrol, Hexoestrol, Hormonestrol, Novostrol, Sintex, Sintovo.
Composition Sinestrol
The active ingredient is hexestrol.
Indications for use
In women, the indications for the use of folliculin are basically the same. Sometimes prescribed for hypertrophy (increase in volume) and prostate cancer in men.
pharmachologic effect
Sinestrol is a synthetic compound - a derivative of stilbene. Its chemical structure differs from steroid estrogen hormones (female sex hormones), but its biological and medicinal properties are close to them. Estrogens are female sex hormones produced by the ovaries and the adrenal cortex, causing the development of female genital organs, secondary sexual characteristics, and also promote the proliferation (growth) of endometrial cells (the inner layer of the uterus).
In terms of estrogenic activity (action similar to the action of female sex hormones - estrogens), Sinestrol is equivalent to folliculin: 1 mg of Sinestrol corresponds to 10,000 units.
Mode of application
Injected intramuscularly, subcutaneously and orally; intramuscularly and subcutaneously - in oil solutions, orally - in tablets. When administered orally, sinestrol is rapidly absorbed; is not destroyed in the gastrointestinal tract.
For hypogenitalism (underdevelopment of the external genitalia), congenital amenorrhea (absence of menstruation) and a severely underdeveloped uterus, use 0.001-0.002 g (1-2 mg) intramuscularly or 0.002 g (2 mg) orally daily for 4-6 weeks. and more. If there is an effect, then progesterone (5 mg per day intramuscularly) or pregnin (10 mg 3 times a day orally) is prescribed for 6-8 days. If necessary, courses of hormone therapy are repeated.
For secondary amenorrhea (cessation of normal menstrual cycles for a period of more than 6 months), 1-2 mg of sinestrol per day is prescribed for 15-20 days, then progesterone or pregnin at the indicated dose for 6-8 days.
For hypooligomenorrhea (scanty short-term menstruation - no more than 2 days), the drug is prescribed 1 mg intramuscularly or orally every day or every other day during the first half of the intermenstrual period; for infertility due to underdevelopment of the uterus - 1 mg intramuscularly or 1-2 mg orally in the first 7-8 days after menstruation; for menopausal disorders, 0.0005-0.001 g (0.5-1 mg) is prescribed orally. The duration of treatment is individualized.
For breast cancer in women over 60 years of age, a 2% solution of sinestrol is used. Administer daily, starting with 1 ml per day, then the daily dose is gradually increased to 5 ml. Through careful observation, the optimal dose is determined and administered over a long period of time.
For prostate cancer, 3-4 ml of a 2% solution (0.06-0.08 g) is administered intramuscularly daily for 2 months, then 0.5-1 ml of a 2% solution per day intramuscularly or orally. The total dose and duration of treatment depend on changes in the prostate gland, the presence or absence of metastases (spread of cancer to other organs and tissues), general condition and degree of feminization (appearance of female secondary sexual characteristics in men / growth of the mammary glands, fat deposition on the thighs, etc. .d./).
Sinestrol and other estrogenic drugs (see fosfestrol, folliculin) in the treatment of malignant neoplasms are usually used in combination with other methods ( surgery, radiation therapy).
Higher doses of sinestrol for adults orally: single - 0.002 g, daily - 0.004 g; into muscles: single - 0.002 g (2 ml of 0.1% solution), daily - 0.003% g. For the treatment of malignant neoplasms, the highest single intramuscular dose is 0.06 g (3 ml of 2% solution), the highest daily dose is 0. 1 g (5 ml of 2% solution).
Interaction with other drugs
No data.
Contraindications
Sinestrol and its analogues are contraindicated during pregnancy, liver and kidney diseases.
Side effect
Sinestrol is usually well tolerated. In some cases, nausea, vomiting, and dizziness occur. When taking large doses, toxic damage to the liver, excessive proliferation of the endometrium (increase in the volume and weight of the inner lining of the uterus) and bleeding in women, pronounced feminization in men (decreased sexual function, swelling of the mammary glands, pigmentation of the nipples, reduction in the size of the testicles, etc.) are possible.
Overdose
No data.
special instructions
Liver and kidney diseases.
Storage conditions
List B. In a place protected from light.
Manufacturer
ICN Polypharm (Russia), Dalkhimfarm (Russia), Moskhimfarmpreparaty im. ON THE. Semashko (Russia), Rostov HPO (Russia), Farmadon (Russia)

Sinestrol Solution for injection, oil 2% - ampoule 1 ml with ampoule knife, box (box) 10 - No. P N000310/01-2001, 2001-03-13 from PharmaDon (Russia) - Expired 2006-05-21

Latin name

Synoestrol

Active substance

Hexestrol*(Hexoestrolum)

ATX

G03CA Natural and semi-synthetic estrogens

Pharmacological groups

Estrogens, gestagens - their homologues and antagonists Antitumor hormonal agents and hormone antagonists

Nosological classification (ICD-10)

C50 Malignant neoplasms of the breast C61 Malignant neoplasms of the prostate E28.3 Primary ovarian failure N40 Prostatic hyperplasia N91 Absence of menstruation, scanty and infrequent menstruation N95.1 Menopausal and menopausal conditions in women N97 Female infertility

Composition and release form

1 ampoule with 1 ml of injection solution in peach oil contains hexestrol 1 mg (0.1%) and 20 mg (2%), in olive oil - 20 mg (2%) - complete with an ampoule knife, 10 pcs in a box .

pharmachologic effect

Pharmacological action - estrogenic.

Indications for the drug Sinestrol

Ovarian hypofunction, amenorrhea, infertility, menopausal disorders in women, prostate adenoma, prostate and breast cancer.

Contraindications

Diseases of the liver, kidneys, pregnancy.

Side effects

Dizziness, nausea, vomiting, liver dysfunction, endometrial hyperproliferation, metrorrhagia, feminization.

Directions for use and doses

V/m. Doses are set individually depending on the diagnosis. As a rule, 1-2 ml of a 0.1% solution (1-2 mg) 2 times a day for 6-8 days or 0.5-5 ml of a 2% solution once a day for a month. The highest single dose for the treatment of malignant tumors is 0.06 g (3 ml - 2% solution), the highest daily dose is 0.1 g (5 ml - 2% solution).

Storage conditions for the drug Sinestrol

In a place protected from light.

Keep out of the reach of children.

Shelf life of the drug Sinestrol

5 years.

Latest update of the description by the manufacturer

31.07.1997

Other packaging options for the drug are Sinestrol.

Sinestrol Solution for injection, oil 0.1% - ampoule 1 ml with ampoule knife, box (box) 10 - EAN code: 4605253001277 - No. P N000310/01-2001, 2001-03-13 from PharmaDon (Russia) - Expired 2006-05 -21 Synestrol Solution for injection, oil 2% - 1 ml ampoule with ampoule knife, box (box) 10- No. P N000310/01-2001, 2001-03-13 from FarmaDon (Russia) - Expired 2006-05-21 Synestrol Solution for oil injection 2% - ampoule 1 ml with ampoule knife, box (box) 10- No. Р N002087/01-2003, 2009-02-05 from Dalkhimpharm (Russia) Synestrol Solution for injection oil 2% - ampoule 1 ml with ampoule knife , box (box) 10 - EAN code: 4605253000010 - No. P N000310/01-2001, 2001-03-13 from PharmaDon (Russia) - Expired date 2006-05-21 Synestrol Solution for injection oil 0.1% - 1 ml ampoule with knife ampoule, box (box) 10 - EAN code: 4602824000417- No. Р N002087/01-2003, 2009-02-05 from Dalkhimpharm (Russia) Sinestrol Solution for injection oil 2% - ampoule 1 ml with ampoule knife, box (box) no. Oil injection solution 0.1% - 1 ml ampoule with ampoule knife, box (box) 10 - No. P N002087/01-2003, 2009-02-05 from Dalkhimpharm (Russia) Sinestrol Substance-powder-bag (bag) double-layer polyethylene 5 kg- No. FS-000266, 2011-12-06 from Dalkhimpharm (Russia)

Manufacturer: PJSC "Biopharma" Ukraine

ATS code: G03С В05

Farm group:

Release form: Liquid dosage forms. Injection.

General characteristics. Compound:

Active ingredient: 1 ml of solution contains hexestrol 1 mg or 20 mg;

excipients: olive oil.

Basic physicochemical characteristics: clear oily liquid of light yellow or golden yellow color.

Pharmacological properties:

Pharmacodynamics. Hexestrol is a synthetic estrogen drug with a non-steroidal structure. Exhibits a specific therapeutic effect: activates the processes of endometrial proliferation, stimulates the development of the uterus and secondary female sexual characteristics when they are underdeveloped, mitigates and eliminates general disorders that arise in a woman’s body due to insufficient function of the gonads during menopause or after gynecological operations, prevents the development .

Pharmacokinetics. Absorption is high, the effect of primary passage through the liver is characteristic. Excreted by the kidneys.

Indications for use:

Hypogenitalism associated with insufficient ovarian function, primary and secondary, hypoplasia of the genital organs, menopausal disorders.

In complex therapy (surgical treatment, radiation therapy) in women over 60 years of age and prostate cancer in men.

Important! Get to know the treatment

Directions for use and dosage:

For hypogenitalism, congenital amenorrhea and a severely underdeveloped uterus - intramuscularly 1-2 mg daily for 4-6 weeks or more.

For secondary amenorrhea - 1-2 mg per day for 15-20 days.

For hypooligomenorrhea - 1 mg intramuscularly daily or every other day during the first half of the intermenstrual period.

For infertility associated with underdevelopment of the uterus - 1 mg intramuscularly for the first 7-8 days after menstruation.

For breast cancer in women over 60 years of age, 1 ml of a 2% solution daily, increasing the daily dose to 5 ml. Through careful observation, the optimal dose is determined and administered over a long period of time.

For prostate cancer, 3-4 ml of a 2% solution intramuscularly daily for 2 months, then 0.5-1 ml of a 2% solution. The total dose and duration of treatment depend on changes in the prostate gland, the presence or absence of metastases, general condition and the degree of feminization.

The highest intramuscular dose for adults: single 0.002 g (2 ml of 1% solution), daily 0.003 g.

In the treatment of malignant neoplasms, the highest intramuscular dose is 0.09 g (3 ml of 2% solution), daily dose is 0.1 g (5 ml of 2% solution).

Features of application:

Use with caution in patients with thrombophlebitis, thrombosis or thromboembolism; pancreatitis, endometriosis, a history of gallbladder disease (especially cholelithiasis), severe liver failure, jaundice, hypercalcemia associated with bone metastases of the mammary gland.

Side effects:

In some cases, an increased risk of thromboembolism is possible. When using large doses, toxic damage to the liver, excessive proliferation of the endometrium and in women, pronounced feminization in men (decreased sexual function, swelling of the mammary glands, pigmentation of the nipples, reduction in the size of the testicles) are possible.

Interaction with other drugs:

Prescribed in combination with progesterone, pregnin.

Contraindications:

Pregnancy, lactation, liver and kidney disease, uterine bleeding, malignant and benign neoplasms in women under 60 years of age, diseases associated with increased levels of blood coagulation, different shapes hyperestrogenism, diabetes mellitus.

Overdose:

No messages.

Storage conditions:

Store in a dry place, protected from light. Shelf life - 5 years.

Vacation conditions:

On prescription

Package:

1 ml of 0.1% oil injection solution in ampoules No. 10.

SINESTROL Sinestrol

Active substance

›› Hexestrol* (Hexestrol*)

Latin name

›› G03CA Natural and semi-synthetic estrogens

Pharmacological groups: Estrogens, gestagens; their homologues and antagonists
›› Antitumor hormonal agents and hormone antagonists

Nosological classification (ICD-10)

›› C50 Malignant neoplasms of the breast
›› C61 Malignant neoplasm of the prostate gland
›› E28.3 Primary ovarian failure
›› N40 Prostatic hyperplasia
›› N91 Absence of menstruation, scanty and infrequent menstruation
›› N95.1 Menopausal and menopausal conditions in women
›› N97 Female infertility

Composition and release form

1 ampoule with 1 ml of solution for injection in peach oil contains hexestrol 1 mg (0.1%) and 20 mg (2%), in olive oil - 20 mg (2%); complete with ampoule knife, 10 pcs per box.

pharmachologic effect

pharmachologic effect- estrogenic.

Indications

Ovarian hypofunction, amenorrhea, infertility, menopausal disorders in women, prostate adenoma, prostate and breast cancer.

Contraindications

Diseases of the liver, kidneys, pregnancy.

Side effects

Dizziness, nausea, vomiting, liver dysfunction, endometrial hyperproliferation, metrorrhagia, feminization.

Directions for use and doses

Best before date

Storage conditions

List B.: In a place protected from light.

* * *

SINESTROL (Synoestrolum). For breast cancer in women over 60 years of age, a 2% solution of sinestrol is used. Administer daily, starting with 1 ml per day, then the daily dose is gradually increased by 5 ml. Through careful observation, the optimal dose is determined and administered over a long period of time. In the case of prostate adenoma, 2 ml of a 2% solution (0.04 g) of sinestrol is administered daily for 30 days. During the year, another 2-3 courses of 20 days are carried out at intervals of 2-3 months. For prostate cancer, 3-4 ml of a 2% solution (0.06-0.08 g) is administered intramuscularly daily for 2 months, then 0.5-1 ml of a 2% solution per day intramuscularly or orally. The total dose and duration of treatment depends on changes in the prostate gland, the presence or absence of metastases, general condition and the degree of feminization. Sinestrol and other estrogenic drugs (see Fosfestrol, Chlortrianizene) in the treatment of malignant neoplasms are usually used in combination with other methods (surgical treatment, radiation therapy). Higher doses of sinestrol for adults orally: single dose 0.002 g, daily dose 0.004 g; into muscles: single 0.002 g (2 ml of 0.1% solution), daily 0.003 g. In the treatment of malignant neoplasms, the highest single dose intramuscularly is 0.06 g (3 ml of 2% solution), the highest daily dose is 0.1 g (5 ml 2% solution). Sinestrol is usually well tolerated. In some cases, nausea, vomiting, and dizziness occur. When taking large doses, toxic damage to the liver, excessive proliferation of the endometrium and bleeding in women, pronounced feminization in men (decreased sexual function, swelling of the mammary glands, pigmentation of the nipples, reduction in the size of the testicles, etc.) are possible. Sinestrol and its analogs are contraindicated during pregnancy, liver and kidney diseases. Release forms: tablets of 0.001 g (1 mg); 0.1% (1 mg in 1 ml) and 2% (20 mg in 1 ml) oil solutions in ampoules of 1 ml; A 2% solution is used only for the treatment of patients with malignant neoplasms. Storage: List B. In a place protected from light.

. 2005 .

Synonyms:

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Sinestrol... Spelling dictionary-reference book

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SINESTROL- (Synoestrolum; PC, list B), a synthetic estrogen hormonal drug. White or slightly yellowish odorless powder; insoluble in water, easily soluble in alcohol and oils. 1 mg of S. contains 10,000 units. Acts similar to... ... Veterinary encyclopedic dictionary

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